About
I am a pharmaceutical scientist with experience in oral solid dosage development, focusing on formulation optimization, powder compaction, and process understanding.
My work combines experimental characterization, DOE, and mechanistic modeling to link material attributes and processing conditions to tablet performance and manufacturability.
Research interests
- Powder compaction and tabletability
- Mechanistic and predictive modeling of manufacturing processes
- Material–process–performance relationships
- Risk-based formulation and process optimization
Selected publications
- Vreeman, G.; Sun, C. C. A strategy to optimize precompression pressure for tablet manufacturing based on in-die elastic recovery. International Journal of Pharmaceutics, 2024, 654, 123981. https://doi.org/10.1016/j.ijpharm.2024.123981
- Vreeman, G.; Sun, C. C. Air entrapment during tablet compression – diagnosis, impact on tableting performance, and mitigation strategies. International Journal of Pharmaceutics, 2022, 121514. https://doi.org/10.1016/j.ijpharm.2022.121514
- Vreeman, G.; Sun, C. C. A powder tabletability equation. Powder Technology, 2022, 117709. https://doi.org/10.1016/j.powtec.2022.117709
- Vreeman, G.; Sun, C. C. Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter. International Journal of Pharmaceutics X, 2021, 3, 100094. https://doi.org/10.1016/j.ijpx.2021.100094
- Vreeman, G.; Wang, C.; Reddy, C. M.; Sun, C. C. Exceptional powder tabletability of elastically flexible crystals. Crystal Growth & Design, 2021, 21 (12), 6655–6659. https://doi.org/10.1021/acs.cgd.1c01017